The 2025 Houston Cougars football team represented the University of Houston in the Big 12 Conference during the 2025 NCAA Division I FBS football season. The Cougars were led by Willie Fritz in his second season as their head coach. The Cougars played their home games at TDECU Stadium, soon to be renamed Space City Financial Stadium, located in Houston, Texas.
The Houston Cougars drew an average home attendance of 32,215, the 68th-highest of all college football teams.