The 2025 Cure Bowl was a college football bowl game played on December 17, 2025, at Camping World Stadium located in Orlando, Florida. The eleventh annual Cure Bowl featured the South Florida Bulls from the American Conference and the Old Dominion Monarchs from the Sun Belt Conference. The game began at approximately 5:00 p.m. EST and aired on ESPN. The Cure Bowl was one of the 2025âÂÂ26 bowl games concluding the 2025 FBS football season. The game was sponsored by StaffDNA, a digital marketplace for healthcare jobs, and was officially known as the StaffDNA Cure Bowl.
The 2025 Cure Bowl featured the Old Dominion Monarchs (9âÂÂ3) of the Sun Belt Conference and the South Florida Bulls (9âÂÂ3) of the American Conference. Old Dominion beat South Florida by a score of 24âÂÂ10.
This was the first time that Old Dominion and South Florida ever played each other.
Old Dominion opened their season with a loss, then won four games in a row. Following back-to-back losses in mid-October, the Monarchs finished their regular season with five consecutive wins. Old Dominion entered the Cure Bowl with a 9âÂÂ3 record.
South Florida compiled a 6âÂÂ1 record in their first seven games, losing only to the fifth-ranked Miami Hurricanes; the Bulls were ranked as high as 18th. South Florida went on to lose two of their final five games. The Bulls entered the Cure Bowl with a 9âÂÂ3 record.
South Florida was led in their bowl game by interim head coach Kevin Patrick, who took over from Alex Golesh (who was hired by Auburn) at the end of November.