The 2025 Copa Sudamericana final stages were played from 15 July to 22 November 2025. A total of 24 teams competed in the final stages to decide the champions of the 2025 Copa Sudamericana, with the final played at Estadio Defensores del Chaco in Asunción, Paraguay.
The winners and runners-up of each of the eight groups in the Copa Sudamericana group stage as well as the third-placed teams of each of the eight groups in the Copa Libertadores group stage advanced to the final stages. The eight Copa Sudamericana group runners-up faced the eight Copa Libertadores group third-placed teams in the knockout round play-offs, whilst the eight Copa Sudamericana group winners directly advanced to the round of 16. <section begin=Qualified teams />
<section begin=Seeding /> For the final stages, the teams were seeded according to their results in the group stage, with the Copa Sudamericana group winners seeded 1âÂÂ8, the Copa Sudamericana group runners-up seeded 9âÂÂ16, and the Copa Libertadores group third-placed teams seeded 17âÂÂ24. For the round of 16 draw, the seeds 1âÂÂ8 made up Pot 1, and the eight knockout round play-offs winners (seeds 9âÂÂ24) made up Pot 2, keeping their seed. Teams from the same association may play each other from the knockout round play-offs onwards. <section end=Seeding />
<section begin=Format /> Starting from the knockout round play-offs, the teams play a single-elimination tournament with the following rules:
<section begin=Draw /> The draw for the round of 16 was held on 2 June 2025, 12:00 PYT () at the CONMEBOL headquarters in Luque, Paraguay. For the round of 16, the 16 teams were drawn into eight ties (AâÂÂH) between a Copa Sudamericana group winner (Pot 1) and a knockout round play-offs winner (Pot 2), with the group winners hosting the second leg. Teams from the same association or the same group could be drawn into the same tie (Regulations Article 2.2.3.2).<section end=Draw />
The bracket starting from the round of 16 is determined as follows:
<section begin=Bracket /> The bracket was decided based on the round of 16 draw, which was held on 2 June 2025.
<section end=Bracket />
The first legs were played on 15âÂÂ17 July, and the second legs were played on 22âÂÂ24 July 2025.
<section begin=Knockout round play-offs /><section end=Knockout round play-offs />
Alianza Lima won 3âÂÂ1 on aggregate and advanced to the round of 16.
Once Caldas won 7âÂÂ0 on aggregate and advanced to the round of 16.
Tied 1âÂÂ1 on aggregate, Atlético Mineiro won on penalties and advanced to the round of 16.
BolÃÂvar won 6âÂÂ0 on aggregate and advanced to the round of 16.
América de Cali won 2âÂÂ0 on aggregate and advanced to the round of 16.
Independiente del Valle won 5âÂÂ1 on aggregate and advanced to the round of 16.
Universidad de Chile won 6âÂÂ2 on aggregate and advanced to the round of 16.
Central Córdoba won 3âÂÂ0 on aggregate and advanced to the round of 16.
The first legs were played on 12âÂÂ14 August, and the second legs were played on 19âÂÂ21 August 2025. <section begin=Round of 16 /><section end=Round of 16 />
Alianza Lima won 4âÂÂ1 on aggregate and advanced to the quarter-finals (Match S1).
BolÃÂvar won 4âÂÂ0 on aggregate and advanced to the quarter-finals (Match S2).
Once Caldas won 4âÂÂ1 on aggregate and advanced to the quarter-finals (Match S3).
Fluminense won 4âÂÂ1 on aggregate and advanced to the quarter-finals (Match S4).
Tied 1âÂÂ1 on aggregate, Lanús won on penalties and advanced to the quarter-finals (Match S4).
Tied 2âÂÂ2 on aggregate, Independiente del Valle won on penalties and advanced to the quarter-finals (Match S3).
Atlético Mineiro won 3âÂÂ1 on aggregate and advanced to the quarter-finals (Match S2).
Independiente was disqualified from the competition and Universidad de Chile advanced to the quarter-finals (Match S1).
The first legs were played on 16âÂÂ18 September, and the second legs were played on 23âÂÂ25 September 2025. <section begin=Quarter-finals /><section end=Quarter-finals />
Universidad de Chile won 2âÂÂ1 on aggregate and advanced to the semi-finals (Match F1).
Atlético Mineiro won 3âÂÂ2 on aggregate and advanced to the semi-finals (Match F2).
Tied 2âÂÂ2 on aggregate, Independiente del Valle won on penalties and advanced to the semi-finals (Match F2).
Lanús won 2âÂÂ1 on aggregate and advanced to the semi-finals (Match F1).
The first legs were played on 21 and 23 October, and the second legs were played on 28 and 30 October 2025. <section begin=Semi-finals /><section end=Semi-finals />
Lanús won 3âÂÂ2 on aggregate and advanced to the final.
Atlético Mineiro won 4âÂÂ2 on aggregate and advanced to the final.
The final was played on 22 November 2025 in Asunción, Paraguay. Estadio Ramón Tahuichi Aguilera in Santa Cruz de la Sierra, Bolivia had been originally selected as the venue for the final, but CONMEBOL announced the change of venue on 11 September 2025 due to delays in the works to prepare the stadium for the event. <section begin=Final /> <section end=Final />