The 2025 Chicago Fire FC season was the club's 28th season in Major League Soccer. This was the club's first season under owner Joe Mansuetto without sporting director Georg Heitz, who stepped down following the previous season's conclusion. It was announced that he, alongside head coach Frank Klopas, would be replaced by former USMNT and Columbus Crew head coach Gregg Berhalter on October 8, 2024, with Berhalter formally taking over on October 20. Following the team's 5-3 victory over Inter Miami on September 30, the club qualified for the playoffs for the first time since 2017. They would also win their first MLS Cup Playoff game since 2009, defeating Orlando 3-1 in the wild card game on October 22. They would ultimately be eliminated in the next round against the Philadelphia Union.
<small>Players signed as of August 22, 2025</small>
<small>Below are players that joined the Fire from Fire II on short-term loans during the season. Players are allowed to be called up to four games and cannot play in more than two games.</small>
Additionally, the Fire brought several academy and Fire II players into preseason camp- goalkeeper Patrick Los, defenders Christopher Cupps, Diego Konincks, and Josue Pfrommer, midfielders Harold Osorio and Sam Williams, and forwards Claudio Cassano and Vitaly Hilyut.
Chicago Fire FC did not qualify for the 2025 Leagues Cup as they were not one of the top 9 teams in the Eastern Conference for the 2024 season.
<small>Note: italics indicates a player who left during the season while * indicates a Fire II player that joined on a short-term loan or for the Open Cup</small>
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