The 2025 Charleston Open (branded as the Credit One Charleston Open for sponsorship reasons) was a professional women's tennis tournament played on outdoor clay courts at the Family Circle Tennis Center on Daniel Island in Charleston, South Carolina. It was the 53rd edition of the tournament and a WTA 500 tournament on the 2025 WTA Tour. It took place from March 31 to April 6, 2025, and was the only event of the clay court season played on green clay.
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following pair received a wildcard into the doubles main draw:
The following pair entered the draw using a protected ranking: