The 2025 season was the 128th in the history of Club de Regatas Vasco da Gama. The club competed in its third consecutive season in the Campeonato Brasileiro Série A. The club also competed in the Campeonato Carioca, Copa do Brasil, and Copa Sudamericana.
Pablo Vegetti was the club's top scorer that season and in all of Brazilian football, with 27 goals, even though he lost his starting position to Rayan at the end of the season. Rayan received the Série A Breakthrough Player award and Paulo Henrique was awarded in Série A Team of the Year.
<small>Players and squad numbers last updated on 26 October 2025. Appearances include all competitions.</small>
The draw took place on 26 November 2024.
|- ! colspan=14 style=background:#dcdcdc; text-align:center| Player(s) who left on loan but featured this season
|- ! colspan=14 style=background:#dcdcdc; text-align:center| Player(s) who left permanently but featured this season |-