The 2025 Buffalo Bulls football team represented the University at Buffalo as a member of the Mid-American Conference (MAC) during the 2025 NCAA Division I FBS football season. Led by second-year head coach Pete Lembo, the Bulls played home games at University at Buffalo Stadium in Amherst, New York.
The MAC Football Kickoff was held on Thursday, July 24, 2025 at Ford Field in Detroit from 9:00 am EDT to 1:30 pm EDT.
On July 24 the MAC announced the preseason coaches poll. Buffalo was picked to finish fourth in the conference.