The 2025 season was the Arizona Cardinals' 106th in the National Football League (NFL), their 38th in Arizona, their 20th playing their homes games at State Farm Stadium, their third under general manager Monti Ossenfort, and their third and final under head coach Jonathan Gannon. Unable to improve on their 8âÂÂ9 record from 2024, the Cardinals missed the playoffs for the fourth straight year with a Week 13 loss to the Tampa Bay Buccaneers, and instead went 3âÂÂ14, setting a franchise record for most losses in a season. The Cardinals started out with a 2âÂÂ0 record, but went a disastrous 1âÂÂ14 the rest of the way, including a nine-game losing streak to end the season. Their .176 winning percentage was their worst since 1959 when they were based in Chicago. Gannon was fired by the Cardinals on January 5, one day following the conclusion of the season, ending his tenure with a 15âÂÂ36 record through three seasons with a meager .294 winning percentage, which is the seventh-worst in NFL history by a coach who has coached at least 50 games. Michael Carter's 333 rushing yards were the lowest by a Cardinal rushing leader since John Grigas also led the team with 333 rushing yards in 1943 when they were, again, the Chicago Cardinals.
Draft trades
The Cardinals lost many players to injury this season, included the loss of Sean Murphy-Bunting and Starling Thomas V before the season started. In week 3, James Conner was lost for the season. The following week Trey Benson suffered a season ending knee injury. In addition first round draft choice Walter Nolen III played just 6 games. Quarterback Kyler Murray was lost for the season. Marvin Harrison Jr. missed 5 games to injury in 2025. Emari Demercado missed 3 games due to injury. Max Melton missed 7 games to injury. Will Johnson did not participate in 5 games. Punter Blake Gillikin missed the final 12 games due to a back injury. Will Hernandez missed the first 4 weeks with an ACL injury. The Cardinals also lost Travis Vokolek and Tip Reiman for the season. Garrett Williams been yet another cardinals cornerback hurt. Zay Jones tore his Achilles tendon and is out for the year. Mack Wilson has been placed on injured reserve with a rib injury. Josh Sweat was hurt in the Cardinals week 16 game and ruled out for the game. Simi Fehoko has been placed on injured reserve for a broken arm, sprained ankle, and a concussion.
|- ! 1 | | Kansas City Chiefs | W 20âÂÂ17 | 1âÂÂ0 | State Farm Stadium | Recap |- ! 2 | | at Denver Broncos | L 7âÂÂ27 | 1âÂÂ1 | Empower Field at Mile High | Recap |- ! 3 | | Las Vegas Raiders | W 20âÂÂ10 | 2âÂÂ1 | State Farm Stadium | Recap
|- ! | September 7 | at New Orleans Saints | W 20âÂÂ13 | 1âÂÂ0 | Caesars Superdome | Recap |- ! | September 14 | Carolina Panthers | W 27âÂÂ22 | 2âÂÂ0 | State Farm Stadium | Recap |- ! | September 21 | at San Francisco 49ers | L 15âÂÂ16 | 2âÂÂ1 | Levi's Stadium | Recap |- ! | | Seattle Seahawks | L 20âÂÂ23 | 2âÂÂ2 | State Farm Stadium | Recap |- ! | October 5 | Tennessee Titans | L 21âÂÂ22 | 2âÂÂ3 | State Farm Stadium | Recap |- ! | October 12 | at Indianapolis Colts | L 27âÂÂ31 | 2âÂÂ4 | Lucas Oil Stadium | Recap |- ! | October 19 | Green Bay Packers | L 23âÂÂ27 | 2âÂÂ5 | State Farm Stadium | Recap |- ! 8 | colspan="6" |Bye |- ! | | at Dallas Cowboys | W 27âÂÂ17 | 3âÂÂ5 | AT&T Stadium | Recap |- ! | November 9 | at Seattle Seahawks | L 22âÂÂ44 | 3âÂÂ6 | Lumen Field | Recap |- ! | November 16 | San Francisco 49ers | L 22âÂÂ41 | 3âÂÂ7 | State Farm Stadium | Recap |- ! | November 23 | Jacksonville Jaguars | L 24âÂÂ27 | 3âÂÂ8 | State Farm Stadium | Recap |- ! | November 30 | at Tampa Bay Buccaneers | L 17âÂÂ20 | 3âÂÂ9 | Raymond James Stadium | Recap |- ! | December 7 | Los Angeles Rams | L 17âÂÂ45 | 3âÂÂ10 | State Farm Stadium | Recap |- ! | December 14 | at Houston Texans | L 20âÂÂ40 | 3âÂÂ11 | NRG Stadium | Recap |- ! | December 21 | Atlanta Falcons | L 19âÂÂ26 | 3âÂÂ12 | State Farm Stadium | Recap |- ! | December 28 | at Cincinnati Bengals | L 14âÂÂ37 | 3âÂÂ13 | Paycor Stadium | Recap |- ! | January 4 | at Los Angeles Rams | L 20âÂÂ37 | 3âÂÂ14 | SoFi Stadium | Recap
Note: Intra-division opponents are in bold text.
Even though quarterback Kyler Murray was feeling ill when he awoke that day he passed for 163 yards, 21/29 attempts, and 2 touchdowns. Despite getting shut out in the fourth quarter, the Cardinals held on to secure a 1âÂÂ0 record. It was the Cardinals' first win in New Orleans since the 1996 season.
Despite taking a 27âÂÂ3 lead into the fourth quarter, the Cardinals had to fend off a late Panthers comeback. Defensive end Calais Campbell sealed the 27âÂÂ22 victory with a game-ending sack on Panthers quarterback Bryce Young, allowing Arizona to hold on for the win. This would turn out to be the Cardinalsâ only home win of the season.
With the loss on a last second field goal, the Cardinals fell to 2âÂÂ1. During the second half star running back James Conner was lost for the season with a gruesome ankle injury.
With their eighth consecutive loss to the Seahawks, and the second consecutive on a last second field goal, the Cardinals fell to 2âÂÂ2.
The Cardinals blew a 21âÂÂ3 lead and suffered an embarrassing defeat, falling to 2âÂÂ3 on the season. Arizona led 21âÂÂ6 entering the fourth quarter before a series of critical mistakes shifted momentum. Running back Emari Demercado appeared to have all but sealed the game with a 72-yard touchdown run with 12:51 remaining, but he dropped the ball just before crossing the goal line, resulting in a touchback. Later in the quarter, safety Dadrion Taylor-Demerson intercepted a pass from Cam Ward but immediately fumbled. Titans receiver Tyler Lockett recovered the ball in the end zone, cutting the Cardinals' lead to 21âÂÂ19 with 4:51 left. After a subsequent punt, the Cardinals allowed the Titans to drive down the field, setting up a 29-yard game-winning field goal by Joey Slye as time expired. The Titans won 22âÂÂ21, snapping a 10-game losing streak and giving rookie quarterback Cam Ward his first NFL victory.
The game also marked the first time in NFL history that a team lost three consecutive games on a field goal as time expired. It was the Cardinals' first home loss to the Titans since the 1997 season, when the franchise was known as the Tennessee Oilers.
On the sideline, head coach Jonathan Gannon lectured Demercado before seemingly hitting him in the arm. Gannon later apologized to Demercado and was fined $100,000 by the team.
Jacoby Brissett started in place of an injured Kyler Murray. Despite a close game, Arizona would find themselves yet again on the losing end, suffering their 4th straight loss falling to 2âÂÂ4.
Despite leading for most of the game, the Cardinals allowed Packers running back Josh Jacobs to score the go-ahead touchdown with under two minutes remaining. Arizona attempted a final comeback, but a critical sack by defensive end Micah Parsons ended any chance of a rally, sealing the Cardinals' fifth consecutive loss.
The Cardinals became the first team in NFL history to lose three consecutive games after leading by 7 or more points entering the fourth quarter. Arizona joined the 2017 49ers and the 1984 Browns as the only teams in NFL history to lose five straight games by four points or fewer. Their five-game losing streak came by a combined total of just 13 points.
With their fourth win against Dallas since 2020, the Cardinals snapped their 5-game losing streak and improved to 3âÂÂ5.
With their ninth loss to the Seahawks, the Cardinals were swept by Seattle for the fourth year in a row and fell to 3âÂÂ6.
The Cardinals were called for a franchise-record 17 penalties, the most by any NFL team prior to Week 15. Despite Jacoby Brissett recording an NFL-record 47 completions, it was not enough, as Arizona was blown out by the 49ers.
The Cardinals lost a close game in overtime 27âÂÂ24. Despite intercepting Trevor Lawrence 3 times and recording 4 turnovers the Cardinals still lost. This marked their first loss to Jacksonville since 2005, snapping a 4 game win streak. The Cardinals scored their first points on a Walter Nolen III 7 yard fumble return. Bam Knight scored on a 1-yard rush in the second quarter. Greg Dortch caught a 39-yard pass from Jacoby Brissett in the fourth quarter. The Cardinals recorded 3 interceptions; one each by Akeem Davis, Garrett Williams, and Budda Baker. Brisket completed 33 of 49 passes for 317 yards and a touchdown and a passer rating of 92.0.
With their 9th loss in their last 10 games, the Cardinals fell to 3âÂÂ9 (2âÂÂ1 against the NFC South) and they were eliminated from playoff contention for the fourth straight season. A few days later Kyler Murray would be ruled out for the rest of the season.
With their fifth straight loss, the Cardinals fell to 3âÂÂ10 and 0âÂÂ5 against the NFC West.
With their sixth straight loss, the Cardinals fell to 3âÂÂ11 and became the only NFC West team to get swept by the AFC South.
With their seventh straight loss, the Cardinals fell to 3âÂÂ12, finished 2âÂÂ2 against the NFC South and 2âÂÂ6 against both southern divisions. Arizona finished 1âÂÂ7 at home.
With the loss, the Cardinals fell to 3âÂÂ13 and finished 0âÂÂ5 against the AFC.
Tight end Trey McBride recorded 10 receptions, giving him 119 on the season and breaking the NFL single-season receptions record for a tight end. He surpassed the previous mark of 116 set by Zach Ertz in 2018.
With the loss, the Cardinals finished dead last in the NFC with a Super Bowl era-franchise worst 3âÂÂ14 record (2âÂÂ7 on the road). Additionally, the Cardinals were swept by all three of their NFC West division rivals (for 0âÂÂ6 division record) for the second time in three seasons.
The following day, the Cardinals fired head coach Jonathan Gannon. During his three-year tenure, Gannon compiled a 15âÂÂ36 record.