The 2025 American Athletic Conference baseball tournament was held at BayCare Ballpark in Clearwater, Florida from May 20 through May 25. The event, held at the end of the conference regular season, determined the champion of the American Athletic Conference for the 2025 season. The East Carolina Pirates won the double-elimination tournament and received the conference's automatic bid to the 2025 NCAA Division I baseball tournament.
This was the last conference tournament under the American Athletic Conference name. In July 2025, the conference dropped the word "Athletic" from its name, renaming itself the American Conference.
The top eight baseball teams in The American were seeded based on their records in conference play. The tournament used a two bracket double-elimination format, leading to a single championship game between the winners of each bracket.