The 2024 Southern Illinois Salukis football team represented Southern Illinois University Carbondale as a member of the Missouri Valley Football Conference (MVFC) during the 2024 NCAA Division I FCS football season. The Salukis were led by ninth-year head coach Nick Hill, and played their home games at Saluki Stadium in Carbondale, Illinois.
The Salukis quarterback room became decimated by injuries throughout the season, with the team turning to graduate assistant Michael Lindauer as quarterback late in the season; Lindauer previously played quarterback for the Salukis before retiring in June 2024. In the team's season finale, Lindauer threw for 7 touchdowns, breaking the program record for passing touchdowns in a single game.
The MVFC released it preseason prediction poll on July 22, 2024. The Salukis were predicted to finish fourth in the conference.