The knockout stage of the 2024 Leagues Cup was the second and final stage of the competition, following the group stage. The knockout stage began on August 7 and concluded with the final on August 25. The top two teams from each group advanced to the knockout stage to compete in a single-elimination tournament. There were 32 matches in the knockout stage, including a third-place playoff played between the two losing semifinalists.
The knockout stage of the 2024 Leagues Cup was contested between the 30 teams that qualified from the group stage and two that received a bye. Matches in the knockout stage were played to a finish. If the score of a match was level at the end of 90 minutes, no extra time was played, and the match was decided by a penalty shoot-out.
The top two placed teams from each of the top fifteen groups qualified for the knockout stage, joining América and Columbus Crew, who both received byes to this round.
The tournament bracket is shown below, with bold denoting the winners of each match.
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<section begin=R32 /><section end=R32 />
<section begin=R16 /><section end=R16 />
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<section begin=SF /><section end=SF />
The winner of the third place match qualified for the first round of the 2025 CONCACAF Champions Cup.
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Both clubs that made the final qualified for the 2025 CONCACAF Champions Cup, with the winner qualifying directly to the round of 16.