The FC Istiklol 2024 season is Istiklol's sixteenth Tajik League season, of which they are defending Tajik League Champions, whilst they also participated in the Tajik Cup, Tajik Supercup and AFC Champions League Two.
On 11 February, Istiklol announced that Igor Cherevchenko and his coaching staff had all left the club after their contracts had expired.
On 26 February, Istiklol confirmed that both Romish Jalilov and Shahrom Sulaymonov had left the club at the end of their contracts, and joined Khosilot Farkhor.
On 15 March 2024, Istiklol announced that Nikola Lazarevic had been appointed as their new Head Coach on a one-year contract.
On 16 March, Istiklol announced the return of Rustam Soirov on a contract until the end of 2025, and the return of Oleksiy Larin on a contract until the end of the season. The following day, 17 March, Istiklol announced the signing of Mekhron Madaminov from Torpedo Miass on a contract until the end of 2025, and the signing of Slavko LukiÃÂ.
On 18 March, Istiklol announced the return of Amirbek Juraboev on a contract until the end of 2025.
On 19 March, Istiklol announced the signing of Murilo Souza on a contract until the end of the season.
On 20 March, Istiklol announced that Khaydar Sattorov and Salokhiddin Irgashev had joined Vakhsh Bokhtar on loan for the season, whilst Shukhratdzhon Shonazarov had joined Khujand on a similar deal. On the same day, Istiklol announced the signing of Keita Suzuki on a contract until the end of the season from Daegu.
On 21 March, Istiklol announced the signing of Blessing Eleke on a contract until the end of the season.
On 22 May, Istiklol's matches against Barkchi on 26 May and Panjshir on 1 June were postponed due to International call ups.
On 16 June, Rustam Yatimov left the club to join Russian Premier League club Rostov for a fee in excess of $250,000.
On 2 July, Istiklol announced that their contracts with Kabir Salimshoev and Alidzhon Karomatullozoda had been terminated by mutual consent.
On 8 July, Istiklol announced the return of goalkeeper Nikola Stoà ¡iÃÂ, on a two-year contract.
On 9 July, Istiklol announced the departure of Slavko LukiÃÂ from the club after his contract expired.
On 12 July, Istiklol announced the departure of Ivan Novoselec and Dà ¾enis Beganoviàafter their contracts had expired, and the signings of Darko Ilieski and Pavel Nazarenko on a contracts until the end of the season.
On 1 August, Istiklol announced the signing of Ruslan Khayloyev who'd most recently played for Tyumen.
On 3 August, Istiklol announced the signing of Matthew Millar who'd most recently played for Macarthur FC and Dimitar Mitkov from Lokomotiv 1929 Sofia both on a contracts until the end of the season.
On 4 August, Istiklol announced the signing of Francesco Margiotta who'd most recently played for BotoÃÂani, to a one-year contract.
On 4 October, Istiklol announced the return of Igor Cherevchenko as their Head Coach.
|- |colspan="16"|Youth team players: |- |colspan="16"|Players away from Istiklol on loan: |- |colspan="16"|Players who left Istiklol during the season: