The 2022 Western Illinois Leathernecks football team represented Western Illinois University as member of the Missouri Valley Football Conference (MVFC) during the 2022 NCAA Division I FCS football season. Led by first-year head coach Myers Hendrickson, the Leathernecks compiled an overall record of 0âÂÂ11 with a mark of 0âÂÂ8 in conference play, placing last out of 11 teams in the MVFC. Western Illinois played home games at Hanson Field in Macomb, Illinois.