The 2022 Vancouver Whitecaps FC season was the club's twelfth season in Major League Soccer, the top division of soccer in the United States and Canada. Including previous iterations of the franchise, this was the 45th season of professional soccer being played in Vancouver under a variation of the "Whitecaps" name.
On November 30, 2021, Vanni Sartini was named the permanent manager after taking over as the acting manager during the 2021 season.
|- ! colspan="14" style=background:#dcdcdc; text-align:center| Goalkeepers
|- ! colspan="14" style=background:#dcdcdc; text-align:center| Defenders
|- ! colspan="14" style=background:#dcdcdc; text-align:center| Midfielders
|- ! colspan="14" style=background:#dcdcdc; text-align:center| Forwards
|- ! colspan="14" style=background:#dcdcdc; text-align:center| Players transferred out during the season