The 2022 U.S. Men's Clay Court Championships (also known as the Fayez Sarofim & Co. U.S. Men's Clay Court Championships for sponsorship purposes) was a tennis tournament played on outdoor clay courts.
It was the 52nd edition of the U.S. Men's Clay Court Championships, and an ATP Tour 250 event on the 2022 ATP Tour. It was originally scheduled to take place at River Oaks Country Club in Houston, Texas, United States for April 6 through April 12, 2020, but this edition of the tournament was postponed to April 4 through April 10, 2022 due to the COVID-19 pandemic.
<sub>*per team</sub>
The following players received wildcards into the main draw:
The following players received entry via the qualifying draw:
The following players received entry as a lucky loser:
The following pairs received a wildcard into the doubles main draw: