The 2022 The Women's Hospital Classic was a professional tennis tournament played on outdoor hard courts. It was the twenty-third edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Evansville, Indiana, United States between 18 and 24 July 2022.
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw: