The 2022 Supersport 300 World Championship was the sixth season of the Supersport 300 World Championship. It started on April 8 at the MotorLand Aragón, and ended on October 9 at the Algarve International Circuit.
The championship was marred by the death of championship runner-up Victor Steeman, who suffered fatal injuries in an accident at the penultimate race of the season at the Algarve International Circuit.