The 2022 Southern Jaguars football team represented Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 2022 NCAA Division I FCS football season. They were led by head coach Eric Dooley, who was coaching his first season with the program. The Jaguars played their home games at A. W. Mumford Stadium in Baton Rouge, Louisiana.
In Southern's first game against Florida Memorial, an NAIA team, they won 86-0. This was the most points Southern had scored since 1949, when they defeated Xavier (LA) 87-0.
Southern finalized their 2022 schedule on February 1, 2022.