The 2022 Saint-Tropez Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Saint-Tropez, France between 10 and 16 October 2022.
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser: