The 2022 Open Harmonie mutuelle was a professional tennis tournament played on hard courts. It was the seventeenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Saint-Brieuc, France between 28 March and 4 April 2022.
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers: