The 2022 Open delle Puglie was a professional tennis tournament played on outdoor clay courts. It was the first edition of the tournament and part of the 2022 WTA 125 tournaments, offering a total of $115,000 in prize money. It took place at the Circolo del Tennis at the Via Martinez in Bari, Italy between 5 and 11 September 2022.
The following players received a wildcard into the singles main draw:
The following players received entry into the main draw through qualification:
The following players entered the main draw as lucky losers:
The following pair received a wildcard into the doubles main draw: