The 17th running of the Omloop Het Nieuwsblad Elite Women in Belgium was held on 26 February 2022. Widely regarded as the start of the Classics season, it was a 1.Pro event on the women's international calendar, part of the UCI Women's ProSeries. The race followed a similar route to that of the men's race, but was shorter and more straightforward at only , starting in Ghent and finishing in Ninove.
The race was won by Dutch rider Annemiek van Vleuten (Movistar Team) for the second time, beating Dutch rival Demi Vollering (SD Worx) in a two-up sprint for the finish.