The 2022 Ole Miss Rebels softball team represented the University of Mississippi in the 2022 NCAA Division I softball season. The Rebels played their home games at the Ole Miss Softball Complex.
The Rebels finished the 2021 season 36âÂÂ22 overall, and 12âÂÂ12 in the SEC to finish in eighth place in the conference. They were invited to the Tucson Regional where they finished 2âÂÂ2.