The 2022 OL Reign season was the team's tenth season of play and their tenth season in the National Women's Soccer League, the top division of women's soccer in the United States.
In December 2021, the team announced that it would start playing its home games at Lumen Field in Seattle, Washington.
All times are in PT unless otherwise noted.
|- |colspan="14" |Goalkeepers: |-
|- |colspan="14" |Defenders: |-
|- |colspan="14" |Midfielders: |-
|- |colspan="14" |Forwards: |-
|- |colspan="14" |Players who left the team during the season: |-
|- |colspan="14" |Own goals for: |-
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For incoming transfers, dates listed are when OL Reign officially signed the players to the roster. Transactions where only the rights to the players are acquired (e.g., draft picks) are not listed. For outgoing transfers, dates listed are when OL Reign officially removed the players from its roster, not when they signed with another team. If a player later signed with another team, her new team will be noted, but the date listed here remains the one when she was officially removed from the OL Reign roster.
Draft picks are not automatically signed to the team roster. Only those who are signed to a contract will be listed as incoming transfers.
Nominees announced on October 14, 2022