The 2022 National Premier Soccer League season was the 20th season of the National Premier Soccer League and part of the 110th season of FIFA-sanctioned soccer in the United States.
The regular season began on March 19 and ended on July 16. In total, 92 teams participated in this season.
The Northwest and Southwest Conferences merged to form the Pacific Conference while the Golden Gate Conference returned to traditional league play. The Lone Star Conference returned to the South Region after temporarily joining the West in 2021.
Note: Teams that are italicized previously played in the NPSL and are returning from hiatus.
<onlyinclude></onlyinclude>
Due to the distance between teams, the Pacific Conference was split into two divisions. The North Division featured Crossfire Redmond, International Portland Select FC and OSA Seattle FC while the South Division included FC Arizona, Las Vegas Legends FC, and SC Brave Lions. Clubs played the other teams within their division three times each and two of the teams in the other division twice each. The top two teams from each group qualified for the playoffs and play one-another in the conference semifinals.
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
<onlyinclude></onlyinclude>
Note: Games are hosted by the highest seed unless noted otherwise
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/> <nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Bold = winner<br/><nowiki>*</nowiki> = after extra time, ( ) = penalty shootout score
Championship MVP: Coby Handy Jean Rodriguez (MOT)