The 2022 Monterrey Open (also known as the Abierto GNP Seguros for sponsorship reasons) was a women's tennis tournament played on outdoor hard courts. It was the 14th edition of the Monterrey Open and a WTA 250 tournament on the 2022 WTA Tour. It took place at the Club Sonoma in Monterrey, Mexico, from February 28 to March 6, 2022. During this tournament, the WTA and other international governing bodies of tennis including the ATP did not have players of Russia and Belarus compete under their country flags as a result of the Russian invasion of Ukraine.
<sub>*per team</sub>
The following players received wildcards into the main draw:
The following player received a special exempt into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following pairs received wildcards into the doubles main draw: