The 2022 Middle Tennessee Blue Raiders football team represented Middle Tennessee State University as a member of Conference USA (C-USA) during the 2022 NCAA Division I FBS football season. They were led by head coach Rick Stockstill, who was coaching his seventeenth season with the team. The Blue Raiders played their home games at Johnny "Red" Floyd Stadium in Murfreesboro, Tennessee.
Middle Tennessee and Conference USA announced the 2022 football schedule on March 30, 2022.