The 2022 Rhein Asset Open was a professional tennis tournament played on clay courts. It was the ninth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Meerbusch, Germany, between 8 and 14 August 2022.
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser: