The 2022 Louisville Cardinals football team represented the University of Louisville during the 2022 NCAA Division I FBS football season. This was the team's fourth season under head coach Scott Satterfield. The Cardinals played their home games at Cardinal Stadium in Louisville, Kentucky, and competed as a member of the Atlantic Coast Conference (ACC).
On December 5, Satterfield announced he would be leaving Louisville to become the head coach at Cincinnati. Director of player personal, Deion Branch, who played wide receiver for Louisville in 2000 and 2001, was named interim head coach for the Cardinals' bowl game.