The 2022 Lexington Challenger was a professional tennis tournament played on outdoor hard courts. It was the twenty-seventh edition of the tournament which was part of the 2022 ATP Challenger Tour, and the twenty-fifth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Lexington, Kentucky, United States between 1 and 7 August 2022.
The following players received a wildcard into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw: