The 2022 Serena Wines 1881 Tennis Cup Internazionali di Tennis del Friuli Venezia Giulia was a professional tennis tournament played on outdoor clay courts. It was the nineteenth edition of the tournament which was part of the 2022 ATP Challenger Tour, and the seventh edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Cordenons, Italy between 25 July and 7 August 2022.
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
The following players received as lucky losers: