The 2022 Houston Cougars football team represented the University of Houston in the 2022 NCAA Division I FBS football season. The Cougars played their home games at TDECU Stadium in Houston, Texas, competing in the American Athletic Conference (The American). They were led by 4th-year head coach Dana Holgorsen. In September 2021, Houston and fellow conference members Cincinnati and UCF accepted bids to join the Big 12 Conference. The schools had been contractually required to remain with The American through 2024, but all reached a separation agreement that allowed them to join the Big 12 in 2023. Accordingly, the 2022 season was the program's last season as a member of The American.
<small>Listed in the order that they were released</small>
The American Athletic Conference preseason media poll was released at AAC Media Day on July 28, 2022. The Cougars were picked to win the conference, edging defending conference champion Cincinnati by one vote.
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