The 2022 Henderson mayoral election was held on June 14, 2022, to elect the next mayor of Henderson, Nevada. Term-limited incumbent Democratic Mayor Debra March decided to run for the Nevada lieutenant gubernatorial election.
Republican Michelle Romero easily won the election. The election was officially non-partisan.
Due to a court ruling regarding the elections for the city council and mayor by the Nevada Supreme Court and changes to the law regarding all elections here statewide by the Nevada Legislature and Governor Steve Sisolak, March was not eligible to run for re-election in 2022 due to term limits.
Romero was considered the heavy favorite, due to her massive fundraising advantage, having raised over $500,000 by the start of 2022, as well as having received several endorsements from well-known local politicians, such as incumbent mayor Debra March and County Commissioner and former mayor James B. Gibson.