The 2022 Grambling State Tigers football team represented Grambling State University as a member of the Southwestern Athletic Conference (SWAC) during the 2022 NCAA Division I FCS football season. They were led by head coach Hue Jackson, who coached his first season with the program. The Tigers played their home games at Eddie Robinson Stadium in Grambling, Louisiana.
Grambling State finalized their 2022 schedule on January 26, 2022.