The 2022 Garden Open was a professional tennis tournament played on clay courts. It was the fourteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Rome, Italy between 25 April and 1 May 2022.
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser: