The 2022 Galway Senior Hurling Championship was the 125th staging of the Galway Senior Hurling Championship since its establishment in 1887. St Thomas' won their fifth consecutive title in a row after defeating Loughrea in a replay at Pearse Stadium on 27 November.
Moycullen participated in the senior championship having beaten Killimor in the 2021 Galway Intermediate Hurling Championship. The competition was sponsored by Brooks for the third of a 3-year partnership that started in 2020.
Tynagh-Abbey/Duniry were relegated, losing the relegation playoff to Ahascragh-Fohenagh and will play in the 2023 Galway Intermediate Hurling Championship.
Killimor won the 2022 Galway Intermediate Hurling Championship and will play Senior B in 2023.
Twenty four teams competed. Twelve teams as determined by the 2021 Competition competed in the Senior A Group and twelve teams competed in the Senior B Group. Eight teams from the Senior A Group and four teams from the Senior B Group progressed to the knockout stage.
Senior A consisted of 12 teams divided into two groups of 6 teams.
Senior B consisted of 12 teams divided into two groups of 6.