The 2022 East Carolina Pirates football team represented East Carolina University during the 2022 NCAA Division I FBS football season. The Pirates played their home games at Dowdy-Ficklen Stadium in Greenville, North Carolina, and competed as members of the American Athletic Conference. They were led by head coach Mike Houston, in his fourth season.
East Carolina signed 18 players in the class of 2022. The Pirates' recruiting class ranks 86th by 247Sports, 91st by On3.com, and 79th by Rivals.
The Pirates will host the three of their non-conference opponents, NC State from the ACC, Old Dominion from Conference USA and Campbell from Division I FCS. They will visit BYU from the FBS Independents