The 2022 Clemson Tigers football team represented Clemson University during the 2022 NCAA Division I FBS football season. The Tigers were led by head coach Dabo Swinney, in his 15th year. The Tigers competed as a member of the Atlantic Coast Conference (ACC) and played their home games at Memorial Stadium in Clemson, South Carolina. On November 26, 2022, the South Carolina Gamecocks defeated Clemson in Memorial Stadium, shattering their nation leading 40 game home winning streak dating back to 2016.
Clemson's 2022 class consisted of 20 signees. The class was ranked first in the ACC and tenth best overall by the 247Sports Composite.
The following players entered the transfer portal during the designated 45 day window after championship selections are made.
<small>Listed in the order that they were released</small>