The 2022 Calgary National Bank Challenger was a professional tennis tournament played on indoor hard courts. It was the third edition of the tournament which was part of the 2022 ATP Challenger Tour and the first edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Calgary, Canada between 7 and 13 November 2022.
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser: