The 2022 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Big Sky Conference during the 2022 NCAA Division I FCS football season. Led by Beau Baldwin in his third and final season as head coach, the Mustangs compiled an overall record of 2âÂÂ9 with a mark of 1âÂÂ7 in conference play, tying for 11th place in the Big Sky. Cal poly played home games at Mustang Stadium in San Luis Obispo, California.
On July 25, 2022, during the virtual Big Sky Kickoff, the Mustangs were predicted to finish tenth in the Big Sky by both the coaches and media.
The Mustangs did not have any players selected to the preseason all-Big Sky team.