Alex de Minaur defeated Jenson Brooksby in the final, 6âÂÂ3, 6âÂÂ3 to win the singles title at the 2022 Atlanta Open. It was de Minaur's second Atlanta title, the first being in 2019.
John Isner was the defending champion, but lost in the quarterfinals to Brooksby.
The top four seeds received a bye into the second round.