The 2022 ATP Lyon Open (also known as the Open Parc Auvergne-Rhône-Alpes Lyon) was a men's tennis tournament played on outdoor clay courts. It was the 5th edition of the Lyon Open and part of the ATP Tour 250 series of the 2022 ATP Tour. It took place in the city of Lyon, France, from 15 May through 21 May 2022. First-seeded Cameron Norrie won the singles title.
<sub>*per team</sub>
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates: