The 2022 AFC Champions League knockout stage was played from 18 August 2022 to 6 May 2023. A total of 16 teams competed in the knockout stage to decide the champions of the 2022 AFC Champions League.
The group winners and three best runners-up in the group stage from each region advanced to the round of 16, with both West Region (Groups AâÂÂE) and East Region (Groups FâÂÂJ) having eight qualified teams. <section begin=Qualified teams /> <section end=Qualified teams />
<section begin=Format /> In the knockout stage, the 16 teams played a single-elimination tournament, with the teams split into the two regions until the final. All ties were played as a single-leg match (Regulations Article 9.1), except for the final, which was played over two legs. Extra time and penalty shoot-out were used to decide the winners if necessary (Regulations Article 9.3 and 10.1).<section end=Format />
The schedule of each round was as follows.
<section begin=Bracket /><section end=Bracket />
<section begin=Combination West/>
<section end=Combination West/> <section begin=Combination East/>
<section end=Combination East/>
<section begin=Round of 16 /> The round of 16 was played over one leg, with the matchups determined by the combination tables based on which group runners-up qualified.
|+West Region
|+East Region
<section end=Round of 16 />
<section begin=Quarter-finals /> The quarter-finals were played over one leg.
|+West Region
|+East Region
<section end=Quarter-finals />
<section begin=Semi-finals /> The semi-finals were played over one leg.
|+West Region
|+East Region
<section end=Semi-finals />
<section begin=Final/> The final was played over two legs.
Urawa Red Diamonds won 2âÂÂ1 on aggregate.<section end=Final/>