2021 Uzbekistan Pro League () was a 30th second-level division competition of Uzbekistan Professional Football League. It was held from April to November 2021. Winner of the tournament - Neftchi qualified for the 2022 Uzbekistan Super League.
"Oqtepa" and "Istiqlol" are out of the tournament. The results of these teams were annulled because they did not play half of their scheduled matches.
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<small>O â games, G â wins, D â draws, M â losses, UG â goals scored, O'G â goals conceded, ñ â goal difference, O â points</small>
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A play-off match for a place in the Super League between the club that finished 3rd in the Pro League and the club that finished 12th in the Super League.