The 2021 UAB Blazers football team represented the University of Alabama at Birmingham (UAB) as a member of the West Division in Conference USA (C-USA) during the 2021 NCAA Division I FBS football season. Led by Bill Clark in his sixth and final season as head coach, the Blazers compiled an overall record of 9âÂÂ4 with a mark of 6âÂÂ2 in conference play, placing second in C-USA's West Division. UAB was invited to the Independence Bowl, where the Blazers defeated BYU. The team played home games at the newly-opened Protective Stadium in Birmingham, Alabama.
UAB announced its 2021 football schedule on January 27, 2021. The 2021 schedule consisted of five home, six away, and one neutral site game in the regular season.