The 2021 Presidential Tour of Turkey was a road cycling stage race that took place between 11 and 18 April 2021 in Turkey. It was the 56th edition of the Presidential Tour of Turkey. The race has previously been a part of the UCI World Tour up until 2019, but it was relegated in 2020. This edition was the race's first as a 2.Pro event on the UCI ProSeries and UCI Europe Tour calendars since its demotion, with the 2020 edition having been cancelled due to the COVID-19 pandemic.
Three UCI WorldTeams, fourteen UCI ProTeams and eight UCI Continental teams participated in the race. Of the twenty-five teams, , , and , with six riders each, were the only ones that did not field the maximum allowed of seven riders. UCI ProTeam was originally invited to participate, but they imposed a self-suspension on racing after one of their riders received a positive anti-doping test. From the 171 riders that started the race, 139 finished.
UCI WorldTeams
UCI ProTeams
UCI Continental Teams
The 2021 edition includes eight stages, up from six in 2019, covering over eight days. The first stage had to be altered due to heavy snow along the original route, reducing the total distance to .