The 18th running of the Tour of Flanders for Women, a women's cycling race in Belgium, was held on 4 April 2021, serving as the 5th event of the 2021 UCI Women's World Tour. It was won for the second time by Annemiek van Vleuten, whose first win in this race came a decade prior.
Nine UCI Women's WorldTeams and fifteen UCI Women's Continental Teams competed in the race. Out of 144 riders that started the race, there were 111 finishers.
UCI Women's WorldTeams
UCI Women's Continental Teams