The 105th edition of the Tour of Flanders (men's race) one-day cycling classic took place on 4 April 2021, as the 12th event of the 2021 UCI World Tour. The race began in Antwerp and covered on the way to the finish in Oudenaarde.
All nineteen UCI WorldTeams and six UCI ProTeams participated in the race, of which only , with six riders, did not enter the maximum of seven riders. From the field of 174 riders, there were 113 finishers.
UCI WorldTeams
UCI ProTeams