The 2021 Tennis in the Land event was a professional women's tennis tournament played on outdoor hard courts at Jacobs Pavilion. It was the first edition of the tournament held in the city of Cleveland in the United States and was a part of the WTA 250 category of the 2021 WTA Tour.
This was Kontaveit's second WTA Tour title, and first since 2017.
<sub><sup>1</sup>Qualifiers prize money is also the Round of 32 prize money.</sub><br> <sub>*per team</sub>
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
The following pair received a wildcard into the doubles main draw:
The following pair received entry using a protected ranking: