The 2021 Supercopa Uruguaya was the fourth edition of the Supercopa Uruguaya, Uruguay's football super cup. It was held on 2 May 2021 between the 2020 Primera División champions Nacional and the 2020 Torneo Intermedio runners-up Montevideo Wanderers, who qualified for the Supercopa since Nacional also won the Torneo Intermedio in the 2020 season.
Nacional won the match by a 2âÂÂ0 score to claim their second Supercopa Uruguaya title in four appearances.